: No. Emulator-specific shader caches (what you download from community sources) are completely separate from the generic driver-level caches used by Windows and GPU drivers. Deleting your NVIDIA or Direct3D cache folders will not affect your Ryujinx shader caches, and vice versa.

try to force a Yuzu cache into Ryujinx. It will crash your emulator. You need a cache built explicitly for Ryujinx.

Ensure that any available pipeline cache toggles are enabled. AMD drivers historically suffered from slow OpenGL shader compilation; switching to Vulkan and keeping pipeline caching active completely eliminates this old bottleneck. Complete vs. Local Shader Caches: The Big Debate

Do not use "Disable Shader Cache" while building. That defeats the purpose.

Never purging your cache. Old shaders from outdated game updates or Ryujinx versions can bloat performance. Every few months, delete your native cache and rebuild fresh.